Edmund C Lattime, PhD

Professor, Surgery, RWJMS The Cancer Institute of New Jersey (CINJ) 195 Little Albany Street, Room 2008 New Brunswick, NJ 08903 lattimec@umdnj.edu http://rwjsurgery.umdnj.edu/FacPopBox.asp?Faculty=38

Clinical Specialty: Immunotherapy, Gene Therapy of Cancer

Degree

• PhD from Rutgers University
• MS from Rutgers University
• Fellowship from Sloan Kettering Institute for Cancer Research
• BA from Gettysburg College

Grants

• Intravesical rF-GMCSF and rF-TRICOM in the treatment of advanced bladder cancer (USPHS NCI)
• In-situ Activation of Anti-Tumor Effectors (USPHS NCI)
• Postdoctoral Training Program in Translational Research in Cancer (USPHS NCI)

Positions

• Deputy Director (05/2008 - Present)
  The Cancer Institute of New Jersey
• Associate Director for Education and Training (07/1998 - Present)
  The Cancer Institute of New Jersey
• Professor (01/1998 - Present)
  Molecular Genetics, Microbiology & Immunology
  Robert Wood Johnson Medical School
• Professor of Surgery (01/1998 - Present)
  Division of Surgical Oncology, Department of Surgery
  Robert Wood Johnson Medical School

Honors

• Scholar Award, Leukemia Society of America
  (1984)
• Young Investigator Award, National Cancer Institute
  (1979)

Society

• American Society of Clinical Oncology (2002 - Present)
• Society for Biologic Therapy (1989 - Present)
• American Association for Cancer Research (1986 - Present)
• American Association of Immunologists (1981 - Present)

Publications

• Strair, R.K., Schaar, D., Medina, D., Todd, M.B., Aisner, J., DiPaola, R.S., Manago, J., Knox, B., Jenkinson, A., Senzon, R., Baker, C., Dudek, L., Ciardella, M., Kuriyan, M., Rubin, A. and Lattime, E.C. Anti-neoplastic effects of partially HLA-matched irradiated blood mononuclear cells in patients with renal cell carcinoma. J. Clin., Oncol.. 2003; 21:3785-3791.
• Yang, A.S. and Lattime, E.C. Tumor-induced IL-10 Suppresses the Ability of Splenic Dendritic Cells to Stimulate CD4 and CD8 T Cell Responses. Cancer Res.. 2003; 63:2150-2157.
• Yang, A.S. and Monken, C.E., and Lattime, E.C. Intratumoral vaccination with vaccinia expressed tumor antigen and GM-CSF overcomes immunological ignorance to tumor antigen. Cancer Research. 2003;

Research

• Our group studies the regulation of immunity to tumors with the overall goal of developing effective immune-based strategies for therapy.
• Immunotherapy of solid tumors; gene therapy of solid tumors; tumor immunology; and cancer vaccines.