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Cell Death and Survival Signaling Program

 

Program Leader: Eileen White, PhD

 

Overall Goals:

To determine the mechanisms regulating tumor cell death and survival and to apply this knowledge to treating human malignancies.


Specific Aims:

  • To define the basic mechanisms of apoptosis inactivation in tumor cells and to develop anti-cancer therapies to restore apoptotic function to achieve tumor regression.
  • To establish the role of metabolism and the metabolic stress resistance mechanism of autophagy in cancer and to modulate the autophagy pathway for cancer prevention and therapy.
  • To identify signal transduction pathways that regulate tumor cell survival and to modulate signaling to achieve therapeutic tumor cell death.

 

Keystone Symposia: Metabolism and Cancer Progression, March 12-17, 2010

Keystone Symposia: Cell Death Pathways: Apoptosis, Autophagy and Necrosis, March 12-17, 2010